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Dr. Santosh Kumar Padhi

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Publications

Publications

  1. Henrike brundiek, Santosh Kumar Padhi, Robert kourist, Andrew Evitt, and Uwe T. Bornscheuer, Altering the scissile fatty acid binding site of Candia antarctica lipase A by protein engineering for the selective hydrolysis of medium chain fatty acids. Eur. J. Lipid Sci. Tech., 2012, 114, 1148-1153.
  2. Santosh Kumar Padhi, Michael Haas, and Uwe T Bornscheuer, Lipase catalyzed transesterification to remove saturated monoglycerides from biodiesel. Eur. J. Lipid Sci. Tech., 2012, 114, 875-879.
  3. Geoffrey A. Behrens, Anke Hummel, Santosh K. Padhi, Sebastian Schätzle and Uwe T Bornscheuer, Discovery and protein engineering of biocatalysts for organic synthesis. Adv. Synth. Catal., 2011, 353, 2191-2215. (All authors contributed equally).
  4. Helge Jochens, Martin Hesseler, Konstanz Stiba, Santosh Kumar Padhi, Romas J Kazlauskas and Uwe T Bornscheuer, Protein engineering of α/β hydrolase fold enzymes. ChemBioChem., 2011, 12, 1508-1517.
  5. Santosh Kumar Padhi, Ryota Fujii, Graig Legatt, Sara Fossum, Reto Berchtold and Romas J Kazlauskas, Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions. Chem. Biol., 2010, 17, 863-871.
  6. Robert Kourist, Helge Jochens, Sebastian Bartsch, Remko Kuipers, Santosh Kumar Padhi, Markus Gall, Dominique Bottcher, Henk-Jan Joosten and Uwe T Bornscheuer, The α/β hydrolase fold 3DM database (ABHDB) as a tool for protein engineering. ChemBioChem., 2010, 11, 1635-1643.
  7. Santosh Kumar Padhi, Despina Boughkou and Jon D Stewart, Site saturation mutagenesis of tryptophan 116 of Saccharomyces pastorianus old yellow enzyme uncovers stereocomplementary variants. J. Am. Chem. Soc., 2009, 131, 3271-3280.
  8. Santosh Kumar Padhi, Iwona A Kaluzna, Didier Buisson, Robert Azerad and Jon D Stewart, Reductions of cyclic β-keto esters by individual Saccharomyces cerevisiae dehydrogenases and a chemo-enzymatic route to (1R,2S)-2-methyl-1-cyclohexanol. Tetrahedron Asymmetry, 2007, 18, 2133-2138.
  9. Santosh Kumar Padhi, D. Titu, N. Ganesh Pandian and Anju Chadha, Deracemisation of β-hydroxy esters using immobilised whole cells of Candida parapsilosis ATCC 7330: Substrate specificity and mechanistic investigation. Tetrahedron, 2006, 62, 5133-5140.
  10. B. Baskar, Santosh Kumar Padhi, N. Ganesh Pandian, T. Vaijayanthi and Anju Chadha, Biocatalytic deracemisaton: An efficient and simple strategy for the preparation of chiral α-and β-hydroxy esters, Chem. Res. Chinese U., 2005, 21(Supplement), 46.
  11. Santosh Kumar Padhi and Anju Chadha, Deracemisation of aromatic β-hydroxy esters using immobilised whole cells of Candida parapsilosis ATCC 7330 and determination of absolute configuration by 1H NMR. Tetrahedron Asymmetry, 2005, 16, 2790-2798.
  12. Santosh Kumar Padhi, N. Ganesh Pandian and Anju Chadha, Microbial deracemisation of aromatic β-hydroxy acid esters.  J. Mol. Catal. B. Enzym., 2004, 29, 25-29.
  13. Santosh Kumar Padhi, N. Ganesh Pandian and Anju Chadha, Microbial deracemisation of β-hydroxy esters - An important strategy towards various chiral intermediates. Chem. Listy, 2003, 97,479-480.
  14. Santosh Kumar Padhi and Anju Chadha, Sodium borohydride reduction and selective transesterification of β-keto esters in one pot reaction. Synlett, 2003, 05, 639-642.


Presentations (* denotes presenter)
  1. Michael J Haas*, Vijay Singh, Santosh Kumar Padhi and Uwe T Bornscheuer, ‘Advances in biodiesel production and quality improvement:  the in situ transesterification of corn germ, and the removal of saturated monoglycerides via enzyme-catalyzed transesterification.’ – Presented in ‘103rd AOCS Annual meeting & Expo’ Long beach, CA, USA, from 29th April - 02nd May 2012 (Oral).
  2. Santosh Kumar Padhi*, and Uwe T Bornscheuer, ‘Laboratory evolution of dehalogenase from esterase’ -Presented in ‘Biotrans 2011’ Sicily, Italy, from 02nd - 06th October 2011(Poster)
  3. Santosh Kumar Padhi*, and Uwe T Bornscheuer, ‘Laboratory evolution of dehalogenase from esterase’ -Paresented in ‘8th European Congress of Chemical Engineering – 1st European Congress of Applied Biotechnology’ Berlin, Germany, from 26th - 29th September 2011 (Poster)
  4. Romas J. Kazlauskas*, Santosh Kumar Padhi, Ryota Fujii, Graig Legatt, Sara Fossum and Reto Berchtold, ‘Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions’ - Presented in ‘5th International Congress on Biocatalysis’ at Hamburg University of Technology, Hamburg, Germany, 29th August to 02nd September 2010 (Poster)
  5. Robert Kourist, Markus Gall*, Helge Jochens, Sebastian Bartsch, Remko Kuipers, Santosh Kumar Padhi, Dominique Bottcher, Henk-Jan Joosten and Uwe T Bornscheuer, ‘The α/β hydrolase fold 3DM database (ABHDB) as a tool for protein engineering’ Presented in ‘5th International Congress on Biocatalysis’ at Hamburg University of Technology, Hamburg, Germany, 29th August to 02nd September 2010 (Poster)
  6. Melissa K Lueder*, Santosh K Padhi, Joel Kooren Ryota Fujii, Amina Lobban and Romas Kazlauskas, ‘Variants of Candida anatarctica lipase B with increased enantioselectivity toward carboxylic acids’ - Presented in ‘National Conference on Undergraduate Research’ at University of Wisconsin-La Crosse, USA,16th -18th April 2009. (Poster)
  7. Romas J. Kazlauskas*, Peter Bernhardt, Ryota Fujii, Tatsiana Gerassenkov, Qing Jing, Helge Jochens, Krzysztof Okrasa, Santosh Padhi, Konstanz Stiba and Uwe Bornscheuer, ‘Teaching enzymes to catalyze new reactions’ Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, 17th -21st August, 2008 (2008), ORGN-392. (Talk)
  8. Santosh Kumar Padhi* and Anju Chadha, ‘Biocatalytic deracemisation of β-hydroxy esters: Substrate specificity and mechanistic investigation’ – Presented in ‘Gordon Research Conference Biocatalysis’ at Bryant University RI, USA, 09th -14th July 2006. (Poster)  
  9. Santosh Kumar Padhi*, N. Ganesh Pandian and Anju Chadha, ‘Synthesis of optically pure β-hydroxy esters: A biocatalytic approach' – Presented in ‘National Symposium-Molecular Basis of Diseases’ at Indian Institute of Technology Madras, 08th -09th January 2005. (Poster)
  10. Santosh Kumar Padhi*, N. Ganesh Pandian and Anju Chadha, ‘Biocatalytic asymmetric synthesis: Deracemisation of b-hydroxy esters’ - Presented in ‘Chemist’s Meet 2004’ at Indian Institute of Technology Madras, 26th -27th March 2004. (Talk)
  11. Santosh Kumar Padhi*, N. Ganesh Pandian and Anju Chadha, ‘Microbial deracemisation of aromatic β-hydroxy acid esters-An important strategy towards various chiral intermediates’-Presented in ‘6th International Symposium on Biocatalysis and Biotransformations’ at Olomouc, Czech Republic, from 28th June to 03rd July 2003. (Poster)
 

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