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Publications

Publications

    

  1. Goyal SG, Dhar A. Downregulation of nesfatin-1 expression in acute kidney injury in vivo in wistar rats and in vitro in cultured cells. Life Sci. 2022 Sep 15;305:120762.
  2. Bhat A, Ghatage T, Bhan S, Lahane GP, Dhar A, Kumar R, Pandita RK, Bhat KM, Ramos KS, Pandita TK. Role of Transposable Elements in Genome Stability: Implications for Health and Disease. Int J Mol Sci. 2022 Jul 15;23(14):7802.
  3.  Dasari D, Bhat A, Mangali S, Ghatage T, Lahane GP, Sriram D, Dhar A. Canagliflozin and Dapagliflozin Attenuate Glucolipotoxicity-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Inhibition of Sodium-Glucose Cotransporter-1. ACS Pharmacol Transl Sci. 2022 Mar 9;5(4):216-225.
  4. Bollareddy SR, Krishna V, Roy G, Dasari D, Dhar A, Venuganti VVK. Transfersome Hydrogel Containing 5-Fluorouracil and Etodolac Combination for Synergistic Oral Cancer Treatment, AAPS PharmSciTech. 2022 Feb 7;23(2):70.
  5. Bhat A, Ghatage T, Bhan S, Lahane GP, Dhar A, Kumar R, Pandita RK, Bhat KM, Ramos KS, Pandita TK. Role of Transposable Elements in Genome Stability: Implications for Health and Disease. Int J Mol Sci. 2022 Jul 15;23(14):7802.
  6. Kulkarni MB, Goyal S, Dhar A, Sriram D, Goel S. Miniaturized and IoT Enabled Continuous-Flow-Based Microfluidic PCR Device for DNA Amplification. IEEE Trans Nanobioscience. 2022. Jan;21(1):97-104.
  7.  Li L, Mangali S, Kour N, Dasari D, Ghatage T, Sharma V, Dhar A, Bhat A. Syzygium cumini (jamun) fruit-extracted phytochemicals exert anti-proliferative effect on ovarian cancer cells. J Cancer Res Ther. 2021 Oct-Dec;17(6):1547-1551.
  1. Mangali S, Bhat A, Dasari D, Sriram D, Dhar A. Inhibition of double stranded RNA dependent protein kinase (PKR) abrogates isoproterenol induced myocardial ischemia in vitro in cultured cardiomyocytes and in vivo in wistar rats. Eur J Pharmacol. 2021 Jun 1;906:174223. 
  2. Udumula MP, Mangali S, Kalra J, Dasari D, Goyal S, Krishna V, Bollareddy SR, Sriram D, Dhar A, Bhat A. High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats. Sci Rep. 2021 Jun 21;11(1):12924. 
  3. Ghatage T, Goyal SG, Dhar A, Bhat A. Novel therapeutics for the treatment of hypertension and its associated complications: peptide- and nonpeptide-based strategies. Hypertens Res. 2021 Jul;44(7):740-755.
  4. Kalra J, Dasari D, Bhat A, Mangali S, Goyal SG, Jadhav KB, Dhar A. PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats. Life Sci. 2020 Dec 1;262:118436. 
  5. Kalra J, Bhat A, Jadhav KB, Dhar A. Up-regulation of PKR pathway contributes to L-NAME induced hypertension and renal damage. Heliyon. 2020 Nov 18;6(11):e05463.
  6. Mangali S, Bhat A, Jadhav K, Kalra J, Sriram D, Vamsi Krishna Venuganti V, Dhar A. Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes. Biochem Pharmacol. 2020 Jul;177:113948.
  7. Kalra J, Mangali S, Bhat A, Jadhav K B, Dhar A. Selective Inhibition of PKR Improves Vascular Inflammation and Remodelling in High Fructose Treated Primary Vascular Smooth Muscle Cells. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165606.
  8. Kalra J, Mangali SB, Dasari D, Bhat A, Goyal S, Dhar I, Sriram D, Dhar A. SGLT1 inhibition boon or bane for diabetes-associated cardiomyopathy. Fundam Clin Pharmacol. 2019 Nov 7. doi: 10.1111/fcp.12516.
  9. Mangali S, Bhat A, Udumula MP, Dhar I, Sriram D, Dhar A. Inhibition of protein kinase R protects against palmitic acid-induced inflammation, oxidative stress, and apoptosis through the JNK/NF-kB/NLRP3 pathway in cultured H9C2 cardiomyocytes. J Cell Biochem. 2019;120(3):3651-3663
  10. Kalra J, Mangali SB, Bhat A, Dhar I, Udumula MP, Dhar A.Imoxin attenuates high fructose induced oxidative stress and apoptosis in renal epithelial cell via downregulation of PKR Pathway.Fundam Clin Pharmacol. 2018 Feb 11.
  11. Udumula MP, Babu MS, Bhat A, Dhar I, Sriram D, Dhar A.High glucose impairs insulin signaling via activation of PKR pathway in L6 muscle cells.Biochem Biophys Res Commun. 2017 May 6;486(3):645-651.
  12. Kalra J, Dhar A.Double-stranded RNA-dependent protein kinase signalling and paradigms of cardiometabolic syndrome.Fundam Clin Pharmacol. 2017 Jun;31(3):265-279.
  13. Dhar A.The Role of PKR as a Potential Target for Treating Cardiovascular Diseases.Curr Cardiol Rev. 2017;13(1):28-31.
  14. Dhar A, Udumula MP, Medapi B , Bhat A , Dhar I, Malapati P, Babu SB, Kalra J, Sriram D, Desai KM. International Journal of Cardiology. 2016 Nov 15;223:581-589.
  15. Udumula MP, Medapi B, Dhar I, Bhat A, Desai K, Sriram D, Dhar A. The Small Molecule Indirubin-3'-Oxime Inhibits Protein Kinase R: Antiapoptotic and Antioxidant Effect in Rat Cardiac Myocytes. Pharmacology. 2016;97(1-2):25-30. 
  16. Dhar A, Dhar I, Bhat A, Desai KM. Alagebrium attenuates methylglyoxal induced oxidative stress and AGE formation in H9C2 cardiac myocytes. Life Sci. 2016 Feb 1;146:8-14.
  17.  Prasad K, Dhar A. Flaxseed and Diabetes. Curr Pharm Des. 2016;22(2):141-4.
  18. Bahal R, Lakhani P, Bhat A, Kondiparthi L, Dhar I, Desai K, Dhar A*. Protein Kinase R and the metabolic syndrome. Journal of Cellular Biotechnology.vol. 1, no. 1, 2015, pp. 53-61.
  19. Dhar A*,  Reddy P, Bhat A, Dhar I, Desai K. Double stranded RNA dependent Protein kinase and type 2 diabetes. Pharmacy and Pharmacology International Journal. P2015, 2(2): 00015.
  20. Pham Nf, Dhar Af, Khalaj S, Desai K, Taghibiglou C. Down regulation of brain cellular prion protein in an animal model of insulin resistance: Possible implication in increased prevalence of stroke in pre-diabetics/diabetic. Biochem Biophys Res Commun. 2014;448:151-156. (f-first two authors equal contribution)
  21. Dhar I, Dhar A, Wu L, Desai,K. Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male sprague-dawley rats.  Am J Hypertens. 2014, 27, 308-316.
  22. Dhar I, Dhar A, Wu L, Desai K. Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats. PLoS One. 2013, 9, e74212. 
  23. Untereiner A, Dhar, A, Liu J, Wu L. Increased renal methylglyoxal formation with down-regulation of PGC-1α-FBPase pathway in cystathionine γ-lyase knockout mice. PLOS One. 2011, 6, e29592.  
  24. Dhar A Dhar I, Jiang, B, Desai, K, Wu L. Chronic methylglyoxal administration by minipump induces pancreatic beta cell dysfunction and type 2 diabetes in Sprague-Dawley rats. Diabetes. 2011, 60, 899-908. (Impact factor: 8.8)
  25. Dhar A, Dhar I, Desai K, Wu L. Methylglyoxal, a glucose metabolite induces endothelial dysfunction: Implications for hyperglycemia. Br J Pharmacol. 2010, 161, 1843-1856. 
  26. Dhar A, Desai K, Wu L. Alagebrium attenuates acute methylglyoxal induces glucose intolerance in Sprague-Dawley rats. Br J Pharmacol. 2010, 159, 166-175. 
  27. Desai K, Chang T, Wang H, Banigesh A, Dhar A, Liu J, Untereiner A, Wu L. Oxidative stress and ageing: Is methylglyoxal the hidden enemy? Can J Physiol Pharmacol. 2010, 88, 273-284. 
  28. Dhar A, Desai K, Liu J, Wu L. Methyglyoxal, protein binding and biological samples: Are we getting the true measure? J Chromatog B. 2009, 877, 1093-10100.
  29. Dhar A, Desai K, Kazachmov M, Yu P,  Wu L. Methylglyoxal production in vascular smooth cells from different metabolic precursors. Metabolism Clin Exptl. 2008, 57, 1211-1220. 
  30. Sharma SS, Dhar A, Kaundal K. FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils, Pharmacol Res. 2007, 55, 335-342.
  31. Roy S, Khanna V, Mittra S, Dhar A, Singh S, Mahajan DC, Priyadarsiny P,  Davis JA,  Sattigeri J, Saini KS, Bansal V. Combination of dipeptidylpeptidase IV inhibitor and low dose thiazolidinedione: Preclinical efficacy and safety in db/db mice. Life Sci. 2007, 81, 72-79. 
  32. Dhar A, Sharma S S, Kaundal K. Neuroprotective effects of FeTMPyP: a peroxynitrite decomposition catalyst in global cerebral ischemia model in gerbils. Pharmacol Res. 2006, 5, 311-316
  33. Sharma SS, Dhar A, Kaundal RK.FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils. Pharmacol Res. 2007 Apr;55(4):335-42.

 

    

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