Patents

Ahil Sajeli Begum, Santosh Kumar S, Onkar P. Kulkarni and Kirti Hira. Indian Patent Application No. TEMP/E-1/18152/2018-DEL (Ref. No. 201811017168). Title: Compounds as Pro-inflammatory cytokine inhibitor (2018/05/07). Patent No. 513419, Granted on 21.02.2024.

Ahil Sajeli Begum, Ameer Basha and Kirti Hira. Indian Patent Application No. TEMP/E-1/38050/2018-DEL (Ref No.201811034856). Title: Pro-inflammatory Cytokine Inhibitory Oral compositions.

List of Publications

Book Chapter

1. Hira K and Sajeli Begum Ahil. Chapter 21: Methods for Evaluation of TNF-α Inhibition Effect. In: Jagadeesh Bayry (Eds): The TNF Superfamily, Methods in Molecular Biology, 2021 Vol. 2248, 271-279, Springer Nature, Humana Press, NY. https://doi.org/10.1007/978-1-0716-1130-2_21.
2. A. Sajeli Begum, A. B. Ray, M. Sahai. “Non-conventional Lignans: Coumarinolignans, Flavonolignans and Stilbenolignans” Progress in the Chemistry of Organic Natural Products. Springer Wien NewYork., June 2010, Vol 93, p 1-70.

Research and Review Articles

1. Nessa S, Lavanya S, Routray RK, Chaurasiya A, Kulkarni OP, Begum AS*. Anti-rheumatoid arthritis potential of Halodule pinifolia: development, characterization and in vivo evaluation of H. pinifolia-based oral suspension and lipid nano-emulsion. Inflammopharmacology. 2024 Apr;32(2):1203-1223. doi: 10.1007/s10787-024-01431-0. [IF 5.8]
2. Pal PP, Lakshmi Soukya PS, Gupta S, Araya H, Fujimoto Y, Begum AS*. Computational analysis followed by in vitro studies to explore cytokines (TNF-α, IL-6 and IL-1β) inhibition potential of the new natural molecule polonilignan. Chem Biol Drug Des. 2024 Mar;103(3):e14486. doi: 10.1111/cbdd.14486 [IF 3.0]
3. Yakkalaa P.A., Rahaman S., Soukya P.S.L., Begum Sajeli A. & Kamal A. An update on the development on tubumin inhibitors for the treatment of solid tumors. Expert Opinion on Therapeutic Targets 2024, https://doi.org/10.1080/14728222.2024.2341630 [IF 5.8]
4. S Shahjahan; Lakshmi Naraharisetti; Alia Begum; Prasanna Yakkala; Lakshmi Soukya; Chandraiah Godugu; Sajeli Begum; Ahmed Kamal. Oxindoline containing thiazolidine-4-one tethered triazoles act as antimitotic agents by targeting microtubule dynamics. Chemistry Select, 2024, DOI: 10.1002/slct.202400539. [IF 2.1]
5. Siva Prakash Pullagara, Arunkumar Thiriveedhi, Venkateswara Rao Battula, Raghunadh Akula, A. Sajeli Begum and Lakshmi Soukya P.S. An efficient ionic liquid medium for the synthesis of new 4-(furan/pyrrole/thiophene-2-yl)-3,4-dihydro-1H-chromeno[4,3-d]pyrimidine-2,5-diones and molecular docking studies. Letters in Organic Chemistry 2024. DOI  10.2174/0115701786289993240215104621
6. Lakshmi PS Soukya and Sajeli A Begum*. Computational Study on Natural Molecules Targeting β-Ketoacyl Reductase Domain of Fatty Acid Synthase for the Identification of Selective Inhibitors. J Biomol Struct Dyn. 2023 Nov 1:1-22. doi: 10.1080/07391102.2023.2273441. [IF 5.23]
7. Sajeli A. Begum and Ahmed Kamal. What are the challenges involved in the strategies for future antibody-drug conjugate discovery and development for oncology? Expert Opinion on Drug Discovery, Apr 2023, https://doi.org/10.1080/17460441.2023.2203910 [IF 7.05]
8. Pragya Paramita Pal, Ahil Sajeli Begum^*, Shaik Ameer Basha, Hiroshi Araya and Yoshinori Fujimoto. New natural pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) and iNOS inhibitors identified from Penicillium polonicum through in vitro and in vivo studies. International Immunopharmacology, 2023 Apr;117:109940. doi: 10.1016/j.intimp.2023.1099402023 [IF 5.714]
9. Pragya Paramita Pal, Ahil Sajeli Begum^*, Shaik Ameer Basha, Hiroshi Araya and Yoshinori Fujimoto. A new lignan (Polonilignan) and inhibitors of nitric oxide production from Penicillium polonicum, an endophytic fungi of Piper nigrum. Chemistry and Biodiversity, 20 Jan 2023,  https://doi.org/10.1002/cbdv.202200840 [2.745]
10. Nikitha Lakshmi; Ameer Basha Shaik; Pragya Paramita Pal; Sajeli Begum Ahil; Ramya Vittal; Saida Naik; Uma Devi Gali; Vidya Sagar Bokka. Piperine, reserpine and b-sitosterol attenuate stem rot (Sclerotium rolfsii Sacc.) of groundnut by inducing the secretion of defense enzymes and phenolic acids. Chemistry and Biodiversity, 19 February 2022, https://doi.org/10.1002/cbdv.202100880 [IF 2.408]
11. Purbali C., Sajeli Begum A., Trinath J., Yogeeswari P. Combining structure-based and 3D QSAR pharmacophore models to discover diverse ligands against EGFR in oral cancer. Future Medicinal Chemistry, 15 Feb 2022, https://doi.org/10.4155/fmc-2021-0205 [IF 3.808]
12. Kirti Hira, Pravesh Sharma, Ashutosh Mahale, Onkar P. Kulkarni, A. Sajeli Begum*. Cyclo(Val-Pro) and Cyclo(Leu-Hydroxy-Pro) from Pseudomonas sp. (ABS-36) alleviates acute and chronic renal injury under in vitro and in vivo models (Ischemic reperfusion and unilateral ureter obstruction). International Immunopharmacology, 2022, vol 103, 108494, https://doi.org/10.1016/j.intimp.2021.108494. [IF 4.932]
13. Lakshmi PS Soukya and Sajeli A Begum*. Review on target domains and natural compound-based inhibitors of fatty acid synthase for anti-cancer drug discovery. Chemical Biology and Drug Design, 2021, doi:10.1111/cbdd.13942 [IF 2.817]
14. Swati Alok, Samrun Nessa and Sajeli Begum. Will she wont she: determinants of complementary and alternative medicines use among female rheumatoid arthritis patients. Advances in Traditional Medicine, 2021, https://doi.org/10.1007/s13596-021-00604-4
15. Sajeli Ahil Begum^*, Kirti Hira, Pragya Paramita Pal, Samrun Nessa, Onkar P. Kulkarni, Jeyapragash Danaraj, Ameer Basha Shaik, Hiroshi Araya, Yoshinori Fujimoto. Halodule pinifolia (Seagrass) attenuated lipopolysaccharide-, carrageenan- and crystal-induced secretion of pro-inflammatory cytokines: Mechanism and Chemistry. Inflammopharmacology, 2020, DOI 10.1007/s10787-020-00747-x [IF 3.238]
16. Santhosh S Kumar, Kirti Hira, Sajeli Begum Ahil*, Onkar P Kulkarni, Hiroshi Araya and Yoshinori Fujimoto. New Synthetic Coumarinolignans as Attenuator of Pro-Inflammatory Cytokines under LPS-Induced Sepsis and Carrageenan-Induced Paw Oedema Models. Inflammopharmacology, 2020 Oct;28(5):1365-1373. doi: 10.1007/s10787-020-00710-w [IF 3.238]
17. Pragya P. Paul, Ameer Basha S., Sajeli Begum Ahil*. Prospective leads from endophytic fungi for anti-inflammatory drug discovery. Planta Medica, 2020 Sep; 86(13-14):941-959. doi: 10.1055/a-1140-8388 [IF 2.687]
18. Swati Alok, Samrun Nessa Sajeli Begum Ahil*. School training strategies for prevention and control of Dengue. Indian J Community Med., 2020, 45 (1), 106-107 [Indexed, SJR 2019 0.3, Q3].
19. Ameer Basha Shaik, Sajeli Begum Ahil*, Ragavendra Govardhan & Pragya Paramita Pal. Management of sorghum grain mold through induced resistance mechanism using foliar spray of Pseudomonas fluorescens strains and non-conventional chemicals: a field study. Archives of Phytopathology and Plant Protection, 2019, 52:11-12, 969-988 [Indexed, SJR 2019 0.23, Q3].
20. A. Sajeli Begum*, Swati Alok and Samrun Nessa. Larval Survey and Spatial Epidemiological Analysis of Vector Aedes aegypti to Study the Risk of Dengue Outbreak in India. GeoJournal, 2019, DOI: 10.1007/s10708-019-10060-y [SJR 2019 0.46, Q2]
21. A. Sajeli Begum*, Kirti Hira, Ameer Basha Shaik, Pragya P. P., Onkar P. Kulkarni, H. Araya and Y. Fujimoto. l-Proline-based-cyclic dipeptides from Pseudomonas sp. (ABS-36) inhibit pro-inflammatory cytokines and alleviate crystal-induced renal injury in mice. International Immunopharmacology, 2019, 73, 395-404. doi.org/10.1016/j.intimp.2019.05.044 [IF 3.943]

22. S. Santhosh Kumar, Ahil Sajeli Begum*, Kirti Hira, Sarfaraj Niazi, B.R. Parshantha Kumar, Hiroshi Araya and Yoshinori Fujimoto. Structure-based design and synthesis of new 4-methylcoumarin-based lignans as pro-inflammatory cytokines (TNF-<alpha>, IL-6 and IL-1<beta>) inhibitors. Bioorganic Chemistry, 2019, 89, 102991, DOI 10.1016/j.bioorg.2019.102991 {IF 4.831]

23. Ameer Basha, S., Sajeli Begum, A*. and Ragavendra, G., Biochemical Characterization of Native Pseudomonas fluorescens Strains followed by their Compatibility with Agrochemicals and Phyto-extracts under in vitro, Int. J. Pure App. Biosci. 2018, 6(6): 117-124. doi: http://dx.doi.org/10.18782/2320-7051.7086

24. Jeyapragash D., Saravana Kumar A., Santosh Kumar S., Sajeli Begum A. “GC-MS Based Metabolomics Analysis and Characterization of Rosmarinic Acid from Tropical Seagrass” International J. Pharmaceutical Research, 2018, 10(4), 277-285. https://doi.org/10.31838/ijpr/2018.10.04.023 [SJR 2019 Q2]
25. A. Sajeli Begum*, S. Santhosh Kumar. “Advances in the chemistry and pharmacological potential of coumarinolignans” Topics in Current Chemistry, 2018, 376:34. https://doi.org/10.1007/s41061-018-0212-5 [IF 7.455]
26. Ahil Sajeli Begum*, Santosh Kumar, Suryanarayana G, Kirti Hira. “O-Glucoside of natural cleomiscosin-A: An attenuator of pro-inflammatory cytokine production” Phytochemistry Letters, 2018, 26, 83-87. https://doi.org/10.1016/j.phytol.2018.05.022 [IF 3.044]
27. Kirti Hira, Ameer Basha, Santosh Kumar, Sajeli Begum Ahil*. “Pseudomonas – a potential source for drug lead discovery” Current Trends in Biomedical Engineering and Biosciences, 2017, 5(5), 555674. DOI: 10.19080/CTBEB.2017.05.555674 [IF 0.822]
28. Poorna Rao, Sajeli Begum*, Mahendra Sahai, Saketh Sriram, “Coptisine, a tetraoxygenated protoberberine alkaloid induces cell cycle arrest at G2/M phase and ROS-dependent mitochondria mediated apoptosis in Non-small cell lung cancer A549 cells” Tumor Biology, 2017, 39 (3), DOI: https://doi.org/10.1177/1010428317694565. [IF 3.650]
29. Pabbati Sanjana, Hira Kirti and Sajeli Begum*. “Medical devices and their approval procedure in India” Int. J. Drug Reg. Affairs 2016, 4(3), 19-29 (DOI: http://dx.doi.org/10.22270/ijdra.v4i3.186).
30. Ameer Basha, Sajeli Begum*, Govardhanam Ragavendra, Mahibalan Senthi, Rukaiyya Khan, Ravi Sojitra, Santhosh Kumar, Asalla  Srinivas, “Antifungal effect and protective role of ursolic acid and three phenolic derivatives in the management of Sorghum grain mold under field conditions” Chemistry and BioDiversity, 2016, 13(9), 1158-1164. doi: 10.1002/cbdv.201500515. [IF 2.039]
31. S Mahibalan, Maria Stephen, T N Rohan, Rukaiyya S Khan, A Sajeli Begum*, “Dermal wound healing potential of betaine and standardized alkaloid enriched ointment of Evolvulus alsinoides in albino rats” Pharmaceutical Biology, 2016, 54(12), 2851-56 (DOI:  10.1080/13880209.2016.1185636). [IF 2.971]
32. P.C. Rao, M.F. J. Ali, Z. H. Jahromi, Saketh S, Sahai M, Ahil Sajeli Begum*, “Cytotoxicity of withasteroids: withametelin induces cell cycle arrest at G2/M phase and mitochondria mediated apoptosis in Non-small cell lung cancer A549 cells” Tumor Biology, 2016, 37, 9, 12579-587, DOI: 10.1007/s13277-016-5128-5 [IF 3.650]
33. Senthi Mahibalan, Poorna Chandra Rao, Rukaiyya Khan, Ameer Basha, Ramakrishna Siddareddy,  Hironori Masubuti, Yoshinori Fujimoto, Ahil Sajeli Begum*, “Cytotoxic constituents of Oldenlandia umbellata and isolation of a new symmetrical coumarin dimer” Medicinal Chemistry Research, 2016, 25, 466-472. DOI: 10.1007/s00044-015-1500-z. [IF 1.783]
34. Rukaiyya Khan, Ameer Basha, Goverdhanam Ragavendra, Poorna Chandra Rao, Yuhei Tanemura, Yoshinori Fujimoto, Ahil Sajeli Begum*, “Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa” Bioorganic and Medicinal Chemistry Letters, 2015, Dec 15;25(24), 5756-61. doi:10.1016/j.bmcl.2015.10.075 [IF 2.572]
35. Rukaiyya Sirajuddin Khan, Mahibalan Senthi, Poorna Chandra Rao, Ameer Basha, Mallika Alvala, Dinesh Tummuri, Hironori Masubuti, Yoshinori Fujimoto, Ahil Sajeli Begum*, “Antiproliferative constituents of Abutilon indicum leaves against U87MG human glioblastoma cells” Natural Product Research, 2015, 29 (11), 1069-1073. DOI: 10.1080/14786419.2014.976643. [IF 2.0]
36. Sajeli Begum Ahil*, Senthi Mahibalan, Shaik Ameer Basha, Ramesh Babu and Katragadda Suresh Babu “Comparative pharmacognostic evaluation and HPTLC analysis of petals of spiny and non-spiny safflower cultivars” 2015, International Journal of Food Properties, 2015, 18 (11), 2561-2570. DOI: 10.1080/10942912.2014.988722
37. S. Mahibalan, A. Sajeli Begum*, Ravi Sojitra, S. Ameer Basha_, Sameer K.  Chandavenkata and C. Sudhakar “Physico-Chemical Characterization of Spineless Safflower Petals and HPLC-Based Process Optimization for Extracting Quercetin-3-O-rutinoside” Journal of Indian Chemical Society, 2014, 91, 1-9.
38. Ameer Basha, Sajeli Begum*, Ragavendra, “Search for agrochemical and heavy metal tolerant strains of Pseudomonas fluorescens and Rhizobium” Indian Journal of Plant Protection 2014, 42 (1), 71-77.
39. Ameer Basha, Sajeli Begum*, Raghavendra, “Effect of various extracts of Annona muricata, Abutilon indicum and Evolvulus alsinoides extract on spore germination of sorghum grain mold fungi” Int. J. Bioresource and Stress Management. 2014, Vol 5(1), 102-106.
40. Sajeli Begum*, Ameer Basha, G. Raghavendra, M. V. Nagesh Kumar, Yukthi Singh, Jagannath V Patil, Yuhei Tanemura, and Yoshinori Fujimoto, “Isolation and characterization of antimicrobial compounds from Pseudomonas fluorescence and their efficacy on sorghum grain mold fungi” Chemistry and BioDiversity, 2014, Vol 11 (1), 92-100.
41. Shaik Ameer Basha, Sajeli Begum*, Raghavendra, Subba Rao, “Sensitivity of Pseudomonas fluorescens and Rhizobium to various antibiotics under in vitro” International Journal of Bioresource and Stress Management”, 2013, Vol 4 (4), 487-491
42. S. Mahibalan, Ruben Sharma, Aditya Vyas, S.  Ameer Basha and A. Sajeli Begum*, “Assessment of extraction techniques for total phenolics and flavonoids from Annona muricata seeds” Journal of Indian Chemical Society, 2013, Dec vol 90, 1-7.
43. Deepali pandey, S. K. Prasad, A. Sajeli Begum, S. Hemalatha and A. K. Wahi, Pharmacognistical standardization and isolation of ergosterol from Melothria maderaspatana Linn. International Journal of Food Properties, 2013, 16 (8), 1871-1882.
44. Araya, H.; Maeda, U.; Hara, N.; Prasad, S.; Begum, A. S.; Sahai, M.; Fujimoto, Y. Potent biologically active tetrahydrofuranic acetogenins from custard apple (Annona reticulate Linn) seeds. Meiji Daigaku Nogakubu Kenkyu Hokoku, 2012, 62 (1), 1-9.
45. S. Mahibalan, A. Sajeli Begum*, S. Ameer Basha and C. V. Sameer Kumar, “Quality control studies on non-spiny hybrid safflower petals as per World Health Organisation (WHO) requirement” J. Oilseeds Res., 2012, 29 (Spl. Issue), 452-455.
46. G. Raghavendra, S. Ameer Basha, M. V. Nagesh Kumar, K. Dharma Reddy, Sajeli Begum*, S. Mahibalan, C. V. Sameer Kumar and M.Suresh, “Effect of safflower petal extraction on spore germination of sorghum grain mold fungi”, J. Oilseeds Res., 2012, 29 (Spl. Issue), 329-332.
47. Sajeli Begum*, Angela Patnaik, S. Ameer Basha, G. Raghavendra, S. K. Pandey and B. K. Sharma, “Effect of leaf extract and steroidal saponin of Cestrum diurnum L. on spore germination and mycelial growth of some fungi” EJEAF Che, 2011, 10(11), 3097-3103.
48. Alvala Ravi, A. Mallika, Venkatesh Sama, A. Sajeli Begum, Rukaiyya S. Khan, B. Madhava Reddy, “Antiproliferative activity and standardization of Tecomella undulate bark extract on K562 cells” Journal of Ethnopharmacology, 2011, Vol 137, 1353-1359.
49.  Sajeli Begum*, Madhur Goyal, “Study of antioxidant and hepatoprotective activities of standardized Cestrum diurnum leaf extract” Ethnopharmacology, 2010, Vol 1 (1).
50.  Sajeli Begum*, “Bioactive non-alkaloidal secondary metabolites of Hyoscyamus niger Linn. Seeds – A Review”, Research Journal of Seed Science, 2010, 3 (4), 210-217.
51.  Sajeli Begum A*., Saxena B, Goyal M, Sairam K., Ch Rao, Ranjan R and Sahai M., “Study of anti-inflammatory, analgesic and anti-pyretic activities of seeds of Hyoscyamus niger L. and isolation of a new coumarinolignan”, Fitoterapia, 2010, 81, 178-184.
52.  Sajeli Begum*, Shweta Verma, Mahendra Sahai, Kathrin Schneider and Roderich Süssmuth, “Hyoscyamal, A New Tetrahydrofuranic Lignan from Hyoscyamus niger Linn”, Natural Product Research, 2009, 23 (7), 595-600.
53. Sajeli Begum* and Madhur Goyal, “A Review on Research and Medicinal Potential of Cestrum”. Pharmacognosy Reviews, 2007, Vol. 1, Issue 2, Jul-Dec, 320-332.

54. Sajeli B. Akhil, M. Sahai, Teigo Asai, Noriyuki Hara, Y. Fujimoto. “Hyosmin, a new Lignan from Hyoscyamus niger Linn.”  J. Chem. Research, 2006, 10, 675-677.

55. Sajeli B. A., Sahai M, Suessmuth R, Teigo Asai, Yoshinori Fujimoto, “Hyosygerin, a new optically active coumarinolignan from the seeds of Hyoscyamus niger” Chem. Pharm. Bull., 2006, 54 (4), 538-541.

56. Sajeli Begum A., Sahai M., Fujimoto Y., Schneider K., Nicholson G., Suessmuth R.D., “A New Kaempferol glycoside from Datura suaveolens Humb & Bonpl. ex Willd” Natural Product Research, 2006, 20 (13), 1231-1236.
57.  Sajeli Begum, Ajay. P. Singh, M. Sahai, S. Singh, Y. Fujimoto, “Two novel Acyl sucroses from Petunia nyctaginiflora. Juss” Indian J. Chem. (Sec B), 2005, 44B, 648-650.
58. Sajeli Begum, U.K. Rai., S. Singh and M. Sahai, “New pairs of acyl sucroses from Petunia nyctaginiflora” J. Ind. Chem. Soc., 2004, 81(6), 495-500.
59. Sajeli Begum, A.P. Singh, M. Singh and M. Sahai, “Chemical constituents of Polyalthia suberosa Thw.”  J. Ind. Chem. Soc, 2004, 81(1), 71-72.
60. P. Singh, A.K. Singh, A. Sajeli Begum and M. Sahai., “Two Acyl sucroses from Petunia nyctaginiflora”, Phytochemistry, 2003, 63(4), 485-489.