Publications

Publications List.

H-Index : 23 Google Scholar Link (https://scholar.google.co.in/citations?hl=en&user=OsMrjUYAAAAJ)

Journal Articles : 41 (First Author : 6, Senior/Corresponding Author: 12)

Conference Abstracts : 16

*Equal Contribution ; # Senior/corresponding author; JIF – Impact Factor (https://jcr.clarivate.com)

JOURNAL ARTICLES

1. Laub V*, Devraj K*, Elias L, Schulte D. Bioinformatics for Wetlab Scientists: Practical Application in Sequencing Analysis. BMC Genomics 2023 (in press)

DOI: 10.1186/s12864-023-09454-7.

JIF - 4.6

2. Spitzer D, Pütz T, Khel MI, Zinke J, Devraj G, Jia X, Sommer K, Filipski K, Freiman T, Thorsen F, Plate KH, Reiss Y, Harter PN, Liebner S, Di Tacchio M, Guérit S*, Devraj K*#. A flow-cytomtery based method for syngenic isolation of neurovascular unit cells and its application to healthy and diseased murine and human neural tissue. Nature Protocols. 2023. (in press)

DOI: 10.1038/s41596-023-00805-y. doi: 10.1186/s12864-023-09454-7.

JIF – 17.1 (# - Senior/corresponding author)

3. Spitzer D, Pütz T, Khel MI, Filipski K, Steinmetz H, Plate KH, Harter PN, Liebner S, Guérit S*, Devraj K*#. Optimization of anti-osteopontin therapy in acute ischemic stroke. Scientific Reports. 2022. (in press)

DOI: 10.1038/s41598-022-25245-8

JIF – 5.0 (# - Senior/corresponding author)

4. Reiss Y, Bauer S, Bastian D, Devraj K, Fidan E, Hattingen E, Liebner S, Nico Melzer N, Meuth SG, Felix Rosenow F, Theodor R, Willems LM, Plate KH. Neurovasculature as a target in epilepsy. Brain Pathology 2022 (in press)

DOI: 10.1111/bpa.13147

JIF – 7.6

5. Schumacher L, Slimani R, Zizmare L, Ehlers J, Borgmann FK, Fitzgerald JC, Fallier-Becker P, Anja Beckmann A, Grissmer A, Meier C, El-Ayoubi A, Devraj K, Mittelbronn M, Trautwein C, Naumann U. TGF-beta modulates the integrity of the blood brain barrier in vitro, associated with metabolic alterations in pericytes. Biomedicines 2022 (in press)

DOI: 10.3390/biomedicines11010214

JIF – 4.8

6. Spitzer D*, Guérit S*, Pütz T, Khel MI, Armbrust M, Dunst M, Zinke J, Devraj G, Jia X, Sommer K,1 K. Filipski K, Freiman T, Looso M, Günther S, Di Tacchio M, Plate KH, Reiss Y, Liebner S, Harter PN, Devraj K#. Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke Acta Neuropathologica. 2022. (in press – June 2022).

DOI: 10.1007/s00401-022-02452-1

JIF – 17.1 (# - Senior/corresponding author)

7. Fouani Y, Kirchhof L, Stanicek L ,Luxán G , Heumüller A, Knau A , Fischer A, Devraj K, John D, Neumann P ,Bindereif A, Boon R , Liebner S, Wittig I , Mogler C, Karimova M, Dimmeler S, Jaé N. The splicing-regulatory lncRNA NTRAS sustains vascular integrity. EMBO Reports 2022 (in press)

DOI: 10.15252/embr.202154157

JIF – 9.1

8. Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d’Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B* Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science 2022 Feb 18;375(6582)

DOI: 10.1126/science.abm4459

JIF – 63.8

9. Hansen L, Lohfink N, Vutukuri R, Khel MI, Kestner RI, Macas J, SpitzerD, Ferreirós N, Gurke R, Günther S, Waltraud Pfeilschifter W*, Devraj K*#. Endothelial sphingosine-1-phosphate receptor 4 regulates blood-brain barrier permeability and promotes a homeostatic endothelial phenotype. Journal of Neuroscience. 2021

DOI: 10.1523/JNEUROSCI.0188-21.2021

JIF – 6.7 (# - Senior/corresponding author)

10. Wirsik NM, Ehlers J, Mäder L, Ilina EI, Blank AE, Grote A, Feuerhake F, Baumgarten P, Devraj K, Harter PN, Mittelbronn M*, Naumann U*. TGF-β activates pericytes via induction of the epithelial to mesenchymal transition protein SLUG in glioblastoma. Neuropathology and Applied Neurobiology. 2021

DOI: 10.1111/nan.12714

JIF – 8.1

11. Winkler L, Blasig R, Breitkreuz-Korff O, Berndt P, Dithmer S, Helms HC, Puchkov D, Devraj K, Kaya M, Qin Z, Liebner S, Wolburg H, Andjelkovic A V, Rex A, Blasig IE, Haseloff RF. Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins. Journal of Cerebral Blood Flow and Metabolism 2021. 41: 132–45.

DOI: 10.1177/0271678X20904687

JIF - 7.0

12. Guérit S, Fidan E, Macas J, Czupalla CJ, Figueiredo R, Vijikumar A, Yalcin BH, Thom S, Winter P, Gerhardt H, Devraj K, Liebner S. Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance. Progress in Neurobiology. 2020. 199: 101937.

DOI: 10.1016/j.pneurobio.2020.101937

JIF – 11.7

13. Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel MI, Heidemann R, Braczynski AK, Ballhorn W, Günther S, Ogunshola OO, Mittelbronn M, Ködel U, Monoranu CM, Plate KH, Hammerschmidt S, Nau R, Devraj K*#, Kempf VAJ*. HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. Acta Neuropathologica. 2020. 140(2):183–208.

DOI: 10.1007/s00401-020-02174-2

JIF – 17.1 (# - Senior/corresponding author)

14. Kestner R-I, Mayser F, Vutukuri R, Hansen L, Günther S, Brunkhorst R, Devraj K*#, Pfeilschifter W*. Gene expression dynamics at the neurovascular unit during early regeneration after cerebral ischemia/reperfusion injury in mice. Frontiers in Neuroscience. Frontiers; 2020;14:280.

DOI: 10.3389/fnins.2020.00280

JIF - 5.2 (# - Senior/corresponding author)

15. Di Tacchio M, Macas J, Weissenberger J, Sommer K, Baehr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Buettner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y. Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF. Cancer Immunology Research. 2019. 7(12): 1910–27.

DOI: 10.1158/2326-6066.CIR-18-0865

JIF – 12.1

16. Bernatz S, Ilina EI, Devraj K, Harter PN, Mueller K, Kleber S, Braun Y, Penski C, Renner C, Halder R, Jennewein L, Solbach C, Thorsen F, Pestalozzi BC, Mischo A, Mittelbronn M. Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. Journal of Experimental & Clinical Cancer Research. 2019. 38(1): 434

DOI: 10.1186/s13046-019-1427-1

JIF – 12.7

17. Dubinski D, Hattingen E, Senft C, Seifert V, Peters KG, Reiss Y*, Devraj K*#, Plate KH*. Controversial roles for dexamethasone in glioblastoma–Opportunities for novel vascular targeting therapies. Journal of Cerebral Blood Flow & Metabolism. 2019. 39(8):1460–8.

DOI: 10.1177/0271678X19859847

JIF - 7.0 (# - Senior/corresponding author)

18. Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreiros N, Schreiber Y, Schroeder K, Devraj K, Popp R, Hattenbach L-O, Pfeilschifter J, Pfeilschifter W. Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. Investigative Ophthalmology & Visual Science 2018. 59(2):653–61.

DOI: 10.1167/iovs.17-22544.

JIF – 4.9

19. Vutukuri R, Brunkhorst R, Kestner R, Hansen L, Bouzas NF, Pfeilschifter J, Devraj K*#, Pfeilschifter W*. Alteration of sphingolipid metabolism as a putative mechanism underlying LPS‐induced BBB disruption. Journal of Neurochemistry. 2018;144(2):172–85.

DOI: 10.1111/jnc.14236

JIF – 5.5 (# - Senior/corresponding author)

20. Devraj K, Guérit S, Macas J, Reiss Y. An in vivo blood-brain barrier permeability assay in mice using fluorescently labeled tracers. Journal of visualized experiments: JoVE; 2018;(132).

DOI: 10.3791/57038.

JIF - 1.4 (first author)

21. Hu J, Dziumbla S, Lin J, Bibli S-I, Zukunft S, de Mos J, Awwad K, Froemel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Mueller OJ, Glaubitz C, Hammes H-P, Popp R, Fleming I. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature. 2017. 552(7684): 248-52.

DOI: 10.1038/nature25013

JIF – 69.5

22. Friedlaender F, Bohmann F, Brunkhorst M, Chae J-H, Devraj K, Koehler Y, Kraft P, Kuhn H, Lucaciu A, Luger S, Pfeilschifter W, Sadler R, Liesz A, Scholtyschik K, Stolz L, Vutukuri R, Brunkhorst R. Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach. Journal of Cerebral Blood Flow & Metabolism. 2017. 37(8):3015–26.

DOI: 10.1177/0271678X16681311

JIF - 7.0

23. Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Guenther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Kuenne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP. Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. Circulation. 2017. 136(1): 65-79.

DOI: 10.1161/CIRCULATIONAHA.116.026991

JIF – 39.9

24. Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovascular Research. 2017. 113(6): 681–91.

DOI: 10.1093/cvr/cvx032

JIF – 13.1

25. Stolz L, Derouiche A, Devraj K, Weber F, Brunkhorst R, Foerch C. Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 2017. 14(1): 1–10.

DOI: 10.1186/s12974-017-0926-2

JIF – 9.6

26. Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T. Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation. Journal of Cerebral Blood Flow & Metabolism. 2017 37(7):2471-84.

DOI: 10.1177/0271678X16669365

JIF - 7.0

27. Ziegler N, Awwad K, Fisslthaler B, Reis M, Devraj K, Corada M, Minardi SP, Dejana E, Plate KH, Fleming I, Liebner S. beta-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. Journal of Neuroscience. 2016. 36(34): 8921–35.

DOI: 10.1523/JNEUROSCI.0148-16.2016

JIF - 6.7

28. Devraj K#, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S. BACE-1 is expressedin the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease. Journal of Cerebral Blood Flow & Metabolism. 2016. 36(7): 1281–94.

DOI: 10.1177/0271678X15606463

JIF - 7.0 (# - Senior/corresponding author)

29. Gurnik S*, Devraj K*, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathologica. 2016. 131(5): 753–73.

DOI: 10.1007/s00401-016-1551-3

JIF – 17.1 (first author)

30. Simpson IA, Ponnuru P, Klinger ME, Myers RL, Devraj K, Coe CL, Lubach GR, Carruthers A, Connor JR. A novel model for brain iron uptake: introducing the concept of regulation. Journal of Cerebral Blood Flow & Metabolism. 2015. 35(1):48–57.

DOI: 10.1038/jcbfm.2014.168

JIF - 7.0

31. Feng Y, Gross S, Wolf NM, Butenschoen VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes H-P, Wieland T. Nucleoside Diphosphate Kinase B Regulates Angiogenesis Through Modulation of Vascular Endothelial Growth Factor Receptor Type 2 and Endothelial Adherens Junction Proteins. Arteriosclerosis Thrombosis & Vascular biology. 2014. 34(10): 2292-300.

DOI: 10.1161/ATVBAHA.114.304239

JIF – 10.5

32. Ridder K, Keller S, Dams M, Rupp A-K, Schlaudraff J, Del Turco D, Starmann J, Macas J, Karpova D, Devraj K, Depboylu C, Landfried B, Arnold B, Plate KH, Hoeglinger G, Sueltmann H, Altevogt P, Momma S. Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation. PLOS Biology. 2014. 12(6): e1001874

DOI: 10.1371/journal.pbio.1001874

JIF – 9.6

33. Paganetti P, Antoniello K*, Devraj K*, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, Muhs A. Increased Efflux of Amyloid-beta Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis. Journal of Alzheimers Disease. 2014. 38(4): 767–86.

DOI: 10.3233/JAD-131091

JIF – 4.5

34. Liu H, Devraj K, Möller K, Liebner S, Hecker M, Korff T. EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells. Thrombosis and Haemostasis. 2014. 112(7):151–63.

DOI: 10.1160/TH13-12-1034

JIF – 6.7

35. Czupalla CJ, Liebner S, Devraj K#. In vitro models of the blood–brain barrier. Methods Molecular Biology 2014. 1135: 415–37.

DOI: 10.1007/978-1-4939-0320-7_34

JIF – 10.7 (# - Senior/corresponding author)

36. Paolinelli R, Corada M*, Ferrarini L*, Devraj K*, Artus C, Czupalla CJ, Rudini N, Maddaluno L, Papa E, Engelhardt B, Couraud PO, Liebner S, Dejana E. Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro. PLoS One. 2013. 8(8): e70233

DOI: 10.1371/journal.pone.0070233

JIF – 3.8

37. Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S. Endothelial Wnt/beta-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression. Journal of Experimental Medicine. 2012. 209(9): 1611–27.

DOI: 10.1084/jem.20111580

JIF – 17.6

38. Devraj K, Klinger ME, Myers RL, Mokashi A, Hawkins RA, Simpson IA. GLUT‐1 glucose transporters in the blood–brain barrier: Differential phosphorylation. Journal of Neuroscience Research. 2011. 89(12):1913–25.

DOI: 10.1002/jnr.22738

JIF – 4.4 (First author)

39. Devraj K, Geguchadze R, Klinger M, Freeman W, Mokashi A, Hawkins R, Simpson I. Improved membrane protein solubilization and clean-up for optimum two-dimensional electrophoresis utilizing GLUT-1 as a classic integral membrane protein. Journal of Neuroscience Methods. 2009;184(1):119–23.

DOI: 10.1016/j.jneumeth.2009.07.016

JIF – 3.0 (First author)

40. Fisher J, Devraj K, Ingram J, Slagle-Webb B, Madhankumar A, Liu X, Klinger M, Simpson IA, Connor J. Ferritin: a novel mechanism for delivery of iron to the brain and other organs. American Journal of Physiology-Cell Physiology. 2007. 293(2):C641-9

DOI: 10.1152/ajpcell.00599.2006

JIF – 5.3

41. Devraj K, Bonassar LJ, MacKay CA, Mason-Savas A, Gartland A, Odgren PR. A New Histomorphometric Method to Assess Growth Plate Chondrodysplasia and Its Application to the Toothless (tl, Csf1 null Osteopetrotic Rat. Connective Tissue Research. 2004. 45(1):1–10.

DOI: 10.1080/03008200490278016

JIF – 3.4

CONFERENCE ABSTRACTS

1. Fidan E, Bader F, Plate KH, Harter P, S Guenther S, Freiman T, Konczalla J, Devraj K, Liebner S Increased expression of chemokine receptor CXCR4 in astrocyte endfeet at the neuro-vascular unit from mesial temporal lobe epilepsy patients with hippocampus sclerosis. Glia 2021 69, E495-E495

2. Hu J, Dziumbla S, Lin J, Bibli S-I, Zukunft S, Devraj K, Sodhi A, Liebner S, Hammes H-P, Popp R, Fleming I. Inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy. Acta Physiologica. 2019. 227: 67-68.

3. Hu J, Dziumbla S, Lin J, Bibli S, Devraj K, Liebner S, Hammes H, Popp R, Fleming I. P377 Inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy. Cardiovascular Research. 2018. 114: S96–S96.

4. Eresch, J., Stumpf, M., Koch, A., Vutukuri, R., Ferreiros, N., Schreiber, Y., Schroder, K., Devraj, K., Popp, R., Huwiler, A. and Hattenbach, L.O., 2018. Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy Investigative Ophthalmology & Visual Science. 2018 59(6), pp.2503-2503.

5. Guérit S, FidanE, Devraj K, C.J. CzupallaCJ, Macas J, ThomS, PlateKH, GerhardtH, Liebner S Astrocyte-derived Wnts regulate brain vascular permeability in mice affecting BBB maintenance

Fluids and Barriers of the CNS 2017, 14(Supp 2):A19

6. Leisegang MS, Fork C, Josipovic I, Richler F, Preussner J, Millers MJ, Epah J, Hofmann P, Anther S, Valasarajan C, Moll F, Heidler J, Ponomareva Y, Maegdefesser L, Uchida S, Kunne C, Sleilos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP. LncRNA MANTIS facilitates endothelial angiogenic function. Acta Physiologica. 2017. 219: 58-58.

7. Stolz L, Brunkhorst R, Devraj K#. Interaction of thrombin and sphingosine-1-phosphate on blood-brain barrier function. Journal of Cerebral Blood Flow & Metabolism 2017. 37: 205–205.

8. Dziumbla S, Hu J, Popp R, Lin J, Devraj K, Hammes H-P, Fleming I. The omega-3 diol 19, 20-dihydroxydocosapentaenoic acid regulates vascular permeability in diabetic retinopathy. Acta Physiologica. 2016. 216:213–4.

9. Demolli S, Doddaballapur A, Stark K, Boon RA, Eckart A, Korff T, Hecker M, Manavski Y, Lucas T, Massberg S, Devraj K, Liebner S, Kaluza D, Dimmeler S. Abstract 15187: Shear Stress-regulated Mir-27b Controls Pericyte Recruitment in vitro and in vivo and Contributes to Vessel Maturation. Circulation. 2015. 32(suppl_3):A15187–A15187.

10. Hu J, Popp R, Dziumbla S, Devraj K, Lin J, Hammes H-P, Fleming I. Pharmacological inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy. Acta Physiologica. 2015. 216: 213-4.

11. Hu J, Popp R, Dziumbla S, Devraj K, Lin J, Hammes H, Fleming I. Inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy in ins2akita mice. Journal of vascular research. 2015. 52.

12. Devraj G, Devraj K, Hammerschmidt S, Kempf V. Role of HIF-1 in Pneumococcal Infections at the Blood-Brain Barrier. International Journal of Medical Microbiology. 2013. 303: 60–60.

13. Reis M, Czupalla CJ, Ziegler N, Devraj K, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Dimmeler S, Plate KH, Liebner S. Endothelial Wnt/beta-catenin signaling reduces vascularization, barrier breakdown and tumor growth in a mouse glioma model. Vascular Pharmacology. 2012. 5(56):332-32.

14. Fisher J, Devraj K, Ingram J, Slagle-Webb B, Madhankumar A, Klinger M, Simpson I, Connor J. FERRITIN-A NOVEL MECHANISM FOR DELIVERY OF IRON TO THE BRAIN AND OTHER ORGANS: P-72. American Journal Of Hematology. 2007. 82(6): 72-72

15. Odgren P, Gartland A, Gartland A, Devraj K, Bonassar L, MacKay C, Mason-Savas A. Osteopetrotic chondrodysplasia in the toothless (CSF-1null) rat: A paradigm for the role of osteoclastogenic factors as integrators of endochondral ossification. Bone. 2004. 34: S38–S38.

BITS Pilani

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