• ER stress, motor neuron disease (ALS), Organellar cross talk, Localized translation and Post-translational control during ER stress, aging

Long-term research goal of the lab is to understand the dynamic signalling events and organellar cross-talk during endoplasmic reticulum (ER) stress, a condition that is central to the pathophysiology of important diseases, e.g. diabetes, neurodegeneration, stroke, and cancer. ER stress is known to primarily affect protein synthesis by shutting down the global translation temporarily and play a key role in maintaining the protein homeostasis. Underlying regulatory events at the post-translational level and changes in organellar communication remain elusive. My research employs system-wide approaches and tools to elucidate these mechanisms. To understand the basic biology and its relation to diseases, we will use various models from yeast to various cell culture model and stem cell-induced motor neuron lines.