- ER stress, motor neuron disease (ALS), Organellar cross talk, Localized translation and Post-translational control during ER stress, aging
Long-term research goal of the lab is to understand the dynamic signalling
events and organellar cross-talk during endoplasmic reticulum (ER) stress, a
condition that is central to the pathophysiology of important diseases, e.g.
diabetes, neurodegeneration, stroke, and cancer. ER stress is known to primarily
affect protein synthesis by shutting down the global translation temporarily and
play a key role in maintaining the protein homeostasis. Underlying regulatory events
at the post-translational level and changes in organellar communication remain
elusive. My research employs system-wide
approaches and tools to elucidate these mechanisms. To
understand the basic biology and its relation to diseases, we will use various
models from yeast to various cell culture model and stem cell-induced motor
neuron lines.
Students pursuing Master Degree interested in an internship are strongly encouraged to apply.
Currently PhD positions are available for students with CSIR/ICMR/DBT-JRF .