Derailed inflammation has been recognized to be one of the contributory factors to origin/progression of various cancers. Interestingly, activation triggered metabolic changes have been proportionately correlated with the outcome of immune cell function. However, the role of host cell-small molecule metabolites derived during the physiological activity of an immune cell in regulating the subsequent fate of the immune cell still remains elusive. So, In our laboratory, we are interested in deciphering the signaling networks and associated immune cell metabolites that may not only contribute towards fine-tuning the immune cell function but also the inflammation-driven cancers.
Preliminary Results: 1. Impact of cholesterol derivatives regulating ER stress and inflammation
2. Secondory metabolites influence the autophagy and impact immune cell function.
3. Activated macrophage driven EMT in epithelial cells is reduced by secondory metabolites
Interested students may choose to work in any of these currently ongoing projects based on their basic research experience.
Master’s students interested in an internship are strongly encouraged to apply.
Master's Students with CSIR/ICMR/DBT-JRF are encouraged to apply for Ph.D. positions.
Current Members of the lab:
1. Sushma S Kumar, Biology (Ph.D. Student, CSIR-JRF)
2. Ashna Fathima, Biology (Ph.D. Student)
3. Purbali, Pharmacy (Ph. D. Student, Co-Supervisor)
Alumni:
1. Dilena (M.E. Thesis Student, Supervisor)
2. Vishal Nanda- IISER-Kolkata (IASc-SRF)
3. Vanshikha Gupta (JRF)
4. Preethi Sanchez (M.E. Thesis Student, Supervisor)5. Geetika (M.E. Thesis Student, Supervisor)
6. Aishwarya, MAHE (B.E. Dissertation, Supervisor, I.A.Sc Summer Intern)
7. Kritika Biswas (JRF)
8. Jaganath Arunachalam (JRF)
9. Shreya Gupta (I.A.Sc Summer Intern)
10. Anjali Singh (JRF)