Original Research Articles (peer-reviewed)

Synthesis versus salvage of ester- and ether-linked phosphatidylethanolamine in the intracellular protozoan pathogen Toxoplasma gondii. Communications Biology, 6(1), 306

 Lyu C, Chen Y, Meng Y, Yang J, Ye S, Niu Z, EI-Debs I, Gupta N*, Shen B* (2023) PMID: 36920199

The mitochondrial pyruvate carrier coupling glycolysis and the TCA cycle is required for the asexual reproduction of Toxoplasma gondii. Microbiology Spectrum, e05043-22

 Chen K, Huang X, Distler U, Tenzer S, Günay-Esiyok Ö, Gupta N* (2023) PMID: 36936814

(2)     Vo KC, Ruga L, Psathaki OE, Franzkoch R, Distler U, Tenzer S, Hensel M, Hegemann P, Gupta N* (2022) PMID: 36382189

Plasticity and Therapeutic Potential of cAMP and cGMP-specific Phosphodiesterases in Toxoplasma gondii. Computational and Structural Biotechnology Journal, 20, 5775-5789

(3)      Wang C, Liu L, Wang T, Liu X, Peng W, Srivastav RK, Zhu XQ, Gupta N, Gasser RB*, Hu M* (2022) PMID: 36405717

H11-induced immunoprotection is predominantly linked to N-glycan moieties during Haemonchus contortus infection. Frontiers in Immunology, 13:1034820

(4)        Xia N, Guo X, Guo Q, Gupta N, Ji N, Shen B*, Xiao L*, Feng Y* (2022) PMID: 36121870

Metabolic flexibilities and vulnerabilities in the pentose phosphate pathway of the zoonotic pathogen Toxoplasma gondii. PLoS pathogens, 18(9), e1010864

(5)       Wang C, Gao W, Yan S, Zhang T, Zhu X-Q, Suo X, Liu X, Gupta N, Hu M* (2021) PMID: 34025939 

Li F, Qing P, Ye L, Gupta N, Hu M* (2021) PMID: 33553419

Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii. Communications Biology, 3(1), 750

Vo Kim Chi, Günay-Esiyok Ö*, Liem N, Gupta N* (2020) PMID: 33335684

The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells. Computational & Structural Biotechnology Journal, 18, 3861-76

Zhou H, Zhou T, Zhang B, Lei W, Yuan W, Shan J, Zhang Y, Gupta N, Hu M* (2020) PMID: 32592810

RIOK-2 is essential for egg hatching in a common parasitic nematode. International Journal of Parasitology, S0020-7519(20)30152-1

Liang X, Cui J, Yang X, Xia N, Li Y, Zhao J, Gupta N*, Shen B* (2020) PMID: 32341123

Acquisition of exogenous fatty acids renders the apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma gondii. Journal of Biological Chemistry, 295(22):7743-7752

Pyruvate homeostasis as a determinant of parasite growth and metabolic plasticity in Toxoplasma gondii. mBio, 10(3). pii: e00898-19

Figueiredo CA, Düsedau HP, Steffen J, Gupta N, Dunay MP, Toth G, Reglödi D, Heimesaat MM, Dunay IR* (2019) PMID: 31192159

Immune-modulatory effects of the neuropeptide pituitary adenylate cyclase-activating polypeptide in acute Toxoplasmosis. Frontiers in Cellular and Infection Microbiology, 9:154

Erler H, Ren B, Gupta N*, Beitz E* (2018) PMID: 30237165

Intracellular parasite Toxoplasma gondii harbors three druggable FNT-type formate and L-lactate transporters in the plasma membrane. Journal of Biological Chemistry, 293(45), 17622-17630

Kong P, Lehmann MJ, Helms BJ, Brouwers JF, Gupta N* (2018) PMID: 29844921

Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle. Cell Discovery, 4:24

Narvaez-Ortiz HY, Lopez AJ, Gupta N*, Zimmermann BH* (2018) PMID: 29623259

A CTP synthase undergoing stage-specific reorganization is essential for the survival of the intracellular parasite Toxoplasma gondii. Frontiers in Cellular and Infection Microbiology, 8:83

Huang G, Zhang S, Zhou CX, Tang X, Li C, Wang C, Tang X, Suo JX, Jia Y, Saeed E-A, Cai J, Yu Z, Cai J, Gupta N, Suo X, Liu X* (2018) PMID: 29440368

Influence of Eimeria falciformis infection on gut microbiota and metabolic pathways in mice. Infection and Immunity, pii: 00073-18

Nitzsche N^§, Günay-Esiyok O^§, Tischer M, Zagoriy V, Gupta N* (2017) PMID: 28726641

A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii. Journal of Biological Chemistry, 292(37), 15225-39

Kong P, Ufermann CM, Zimmermann DLM, Yin Q, Suo X, Helms JB, Brouwers JF, Gupta N*(2017) PMID: 28314772

Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii. Journal of Biological Chemistry, 292(17), 7145-59

Sugi T, Ma YF, Tomita T, Murakoshi F, Eaton MS, Yakubu R, Han B, Tu V, Kato K, Kawazu SI, Gupta N, Suvorova ES, White MW, Kim K, Weiss LM* (2016) PMID: 27247232

Toxoplasma gondii cAMP-dependent protein kinase subunit 3 is involved in the switch from tachyzoite to bradyzoite development. mBio, 7(3), e00755-16

Kuchipudi A, Arroyo-Olarte RD, Hoffmann F, Brinkmann V, Gupta N* (2016) PMID: 28357357

Optogenetic monitoring of the parasite calcium identifies a phosphatidylthreonine-regulated ion homeostasis in Toxoplasma gondii. Microbial Cell, 3(5), 215-23

Nitzsche R, Zagoriy V, Lucius R, Gupta N* (2016) PMID: 26518878

Metabolic cooperation of glucose and glutamine is essential for the lytic cycle of obligate intracellular parasite Toxoplasma gondii. Journal of Biological Chemistry, 291(1), 126-41

Arroyo-Olarte RD, Burrowers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N*(2015) PMID: 26565995

Phosphatidylthreonine and lipid-mediated control of parasite virulence. PLoS Biology, 13(11), e1002288

Blume M, Nitzsche R, Sternberg U, Gerlic M, Masters SL, Gupta N, McConville MJ*(2015) PMID: 26269956

A Toxoplasma gondii gluconeogenic enzyme contributes to robust central carbon metabolism and is essential for replication and virulence. Cell Host & Microbe, 18(2), 210-20

Hartmann A, Hellmund M, Lucius R, Voelker DR, Gupta N* (2014) PMID: 24429285

Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii. Journal of Biological Chemistry, 289(10), 6809-24

Schmid M, Heitlinger E, Spork S, Mollenkopf HP, Lucius R, Gupta N* (2014) PMID: 24368565

Hartmann A^§, Arroyo-Olarte RD^§, Imkeller K, Hegemann P, Lucius R, Gupta N* (2013) PMID: 23525100

Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of parasite cAMP for host-cell invasion and stage differentiation. Journal of Biological Chemistry, 288(19), 13705-17

Qureshi B^§, Hoffmann N^§, Arroyo-Olarte RD, Nickl B, Höhne W, Jungblut P, Lucius R, Scheerer P*, Gupta N* (2013) PMID: 23233536

Dynein Light Chain 8a of Toxoplasma gondii, a unique conoid-localized β-strand-swapped homodimer, is required for an efficient parasite growth. FASEB Journal, 27(3), 1034-47

Gupta N*, Hartmann A, Lucius R, Voelker DR* (2012) PMID: 22563079 

The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase. Journal of Biological Chemistry, 287(27), 22938-47

Schmid M, Lehmann MJ, Lucius R, Gupta N* (2012) PMID: 22535959

Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in the mouse. Journal of Biological Chemistry, 287(24), 20197-207

Sampels V, Hartmann A, Dietrich I, Coppens I, Sheiner L, Striepen B, Herrmann A, Lucius R, Gupta N* (2012) PMID: 22451671

Conditional mutagenesis of a novel choline kinase demonstrates the plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii. Journal of Biological Chemistry, 287(20), 16289-99

Blume M, Hliscs M, Contreras D, Sanchez M, Landfear S, Lucius R, Matuschewski K, Gupta N*(2011) PMID: 21169382

A constitutive pan-hexose permease in Plasmodium and models for high-throughput screening of anti-malarial sugar analogs. FASEB Journal, 25(4), 1218-29

Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, Qiao A, Kong X, Liu Y, Chen Q, Gupta N, Fang F, Chang Y*(2010) PMID: 20561910

PGC-1b-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRa. Mitochondrion, 10(5), 516–27

Zhu LL, Liu Y, Cui AF, Shao D, Liang JC, Liu XJ, Chen Y, Gupta N, Fang FD, Chang Y* (2010) PMID: 20215575

PGC-1a coactivates estrogen receptor a to induce the expression of glucokinase. American Journal of Physiology Endocrinology Metabolism, 298(6), E1210–8

Kong X, Fan H, Liu X, Wang R, Liang J, Gupta N, Chen Y, Fang F, Chang Y* (2009) PMID: 19602572

Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Molecular Pharmacology, 76(4), 854-60

Blume M, Contreras DR, Landfear S, Fleige T, Soldati DF, Lucius R, Gupta N* (2009) PMID: 19617561

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis. Proceedings of National Academy of Sciences USA, 106(31), 12998–3003

Liu X, Feng Q, Chen Y, Zuo J, Gupta N, Chang Y*, Fang F (2009) PMID: 19125585

Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. Journal of Proteome Research, 8(3), 1255-62

Jiang ZB, Song HT, Gupta N, Ma LX, Wu ZB* (2007) PMID: 17709259

Cell surface display of functionally active lipases from Yarrowia lipolytica in Pichia pastoris. Protein Expression Purification, 56(1), 35-9

Yang C, Yang Y, Gupta N, Liu X, He A, Liu L, Zuo J, Chang Y*, Fang F (2007) PMID: 17922643

Pentaspan membrane glycoprotein, prominin-1, is involved in glucose metabolism and cytoskeleton alteration. Biochemistry (M), 72(8), 854-62

He A, Zhu L, Gupta N, Chang Y*, Fang F (2007) PMID: 17652184

Overexpression of miR-29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Molecular Endocrinology, 21(11), 2785-94

Liu XJ, Yang C, Gupta N, Zuo J, Chang YS*, Fang FD (2007) PMID: 17619838

Protein kinase C-ζ regulation of GLUT4 translocation by actin remodeling in CHO cells. Journal of Molecular Medicine, 85(8), 851–61

Gupta N, Zahn MM, Coppens I, Joiner KA, Voelker DR* (2005) PMID: 15708856

Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. Journal of Biological Chemistry, 280(16), 16345–53 

Review and Perspective Articles (peer-reviewed)

Günay-Esiyok Ö*, Gupta N* (2020) PMID: 32191852

Chimeras of P4-ATPase and guanylate cyclase in pathogenic protists. Trends in Parasitology, 36 (4), 382-92

Arroyo-Olarte RD, Thurow L, Kozjak-Pavlovic V, Gupta N* (2018) PMID: 30001435

Illuminating pathogen-host intimacy through optogenetics. PLoS Pathogens, 14 (7): e1007046

Ren B, Gupta N* (2017) PMID: 28730142

Taming parasites by tailoring them. Frontiers in Cellular and Infection Microbiology, 7 (292), 1-7

Arroyo-Olarte RD and Gupta N* (2016) PMID: 28357353

Phosphatidylthreonine: an exclusive phospholipid regulating calcium homeostasis and virulence in a parasitic protest. Microbial Cell, 3(5), 189-90

Other Publications (feature articles in science magazines)

Gupta N* (2018)

Optobiology in infection: Host-pathogen interplay in the limelight

EU Research (PDF)

Gupta N* (2013)

Exploiting the Host: Parasite-host interactions

International Innovation (PDF)

^*  Communication authorship                 ^§ Equal contribution authors