BITS Pilani

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Publications

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Publications

Research Articles

  • Goru SK, Gaikwad AB. (2018) Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy. Pharmacological Reports, 70 : 497–502. [Impact Factor:2.587]
  • Kadakol A, Malek V, Goru SK, Pandey A, Gaikwad AB. (2017) Telmisartan and esculetin combination ameliorates type 2 diabetic cardiomyopathy by reversal of H3, H2A, and H2B histone modifications. Indian J Pharmacol, 49(5):348-356. [Impact Factor: 0.68]
  • Kadakol A, Goru SK,  Malek  V,  Gaikwad AB (2017) "Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgfβ1 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats". Biomed Pharmacother.  95: 1461–1468. [Impact Factor: 2.759]
  • Goru SK, Kadakol A, Malek V, Pandey A, Sharma N, Gaikwad AB (2017) "Diminazene aceturate prevents type 1 diabetic nephropathy through increasing glomerular ACE2 and AT2 receptor expression". Br J Pharmacol. 174, 3118-3130. [Impact Factor: 5.491]
  • Kadakol A, Malek V, Goru SK, Pandey A, Sharma N, Gaikwad AB (2017) "Esculetin ameliorates insulin resistance and type 2 diabetic nephropathy through reversal of histone H3 acetylation and H2A lysine 119 monoubiquitination". J Funct Foods. 35, 256-266. [Impact Factor: 3.973]
  • Pandey A, Gaikwad AB (2017) "Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis". Biochem Biophys Res Commun. 487(4), 827–833. [Impact Factor: 2.371]
  • Pandey A, Priyank R, Goru SK, Kadakol A, Malek V, Sharma N, Gaikwad AB (2017) "Esculetin ameliorates hepatic fibrosis in high fat diet induced non-alcoholic fatty liver disease by regulation of FoxO1 mediated pathway". Pharmacological reports. 69(4), 666-672. [Impact Factor: 2.251]
  • Pandey A, Goru SK, Kadakol A, Malek V, Sharma N, Gaikwad AB (2016) "H2AK119 monoubiquitination regulates angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats". Biochimie. 131: 68-76. [Impact Factor: 3.017]
  • Goru SK, Kadakol A, Pandey A, Malek V, Sharma N, Gaikwad AB (2016) "Histone H2AK119 and H2BK120 Monoubiquitination Modulate SET7/9 and SUV39H1 in Type 1 Diabetes Induced Renal Fibrosis". Biochem J. DOI:10.1042/BCJ20160595 [Impact Factor: 3.562]                                
  • Kadakol A, Pandey A, Goru SK, Malek V and Gaikwad AB (2015) "Insulin Sensitizing and Cardioprotective Effects of Esculetin and Telmisartan combination by Attenuating Ang II Mediated Vascular Reactivity and Cardiac Fibrosis". Eur J Pharmacol. 765:591-7. [Impact Factor: 2.730]
  • Pandey A, Goru SK, Kadakol A, Malek  V, and Gaikwad AB (2015) “Differential Regulation of ACE2 and NF-κB by Ang II Receptor Subtypes in Type 2 Diabetic Kidney”. Biochimie. 118: 71-81. [Impact Factor: 3.017]
  • Kadakol A, Malek V, Goru SK, Pandey A, and Gaikwad AB (2015) "Esculetin Reverses Histone H2A/H2B Ubiquitination, H3 Dimethylation, Acetylation and Phosphorylation in preventing Type 2 Diabetic Cardiomyopathy". J Funct Foods. 17:127–136. [Impact Factor: 3.973]
  • Kadakol A, Malek V, Goru SK, Pandey A, Bagal MB and Gaikwad AB (2015) "Esculetin Attenuates Alterations in Ang II and Acetylcholine Mediated Vascular Reactivity Associated with Hyperinsulinemia and Hyperglycemia". Biochem Biophys Res Commun. 461(2), 342–347. [Impact Factor: 2.371]
  • Kumar P, Prashanth KS, Gaikwad AB, Vij M, Barua CC, Bezbaruah B (2013) Disparity in actions of rosiglitazone against cisplatin-induced nephrotoxicity in female Sprague-Dawley rats. Environ Toxicol Pharmacol. 36(3):883-890. [Impact Factor: 2.187]
  • Gaikwad AB, Gupta J, Tikoo K (2010) Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. Biochem J 432(2): 333- 341. [Impact Factor: 3.562]
  • Gaikwad AB, Sayyed SG, Lichtnekert J, Tikoo K, Anders HJ (2010 ) Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy - related genes in type 2 diabetes. Am J Pathol 176(3): 1079- 1083. [Impact Factor: 4.206]
  • Sayyed SG, Gaikwad AB, Lichtnekert J, Kulkarni O, Eulberg D, Klussmann S, Tikoo K, Anders HJ (2010) Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10. Nephrol Dial Transplant 25(6): 1811- 1817. [Impact factor: 4.085]
  • Mulay SR, Gaikwad AB, Tikoo K (2010) Combination of aspirin with telmisartan suppresses the augmented TGFbeta/smad signaling during the development of streptozotocin- induced type I diabetic nephropathy. Chem Biol Interact 185(2): 137- 142. [Impact Factor: 2.618]
  • Gupta J, Gaikwad AB, Tikoo, K (2010) Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats. J Cell Biochem 111(4): 944- 954. [Impact Factor: 3.446]
  • Chandak PG, Gaikwad AB, Tikoo K (2009) Gallotannin ameliorates the development of streptozotocin- induced diabetic nephropathy by preventing the activation of PARP. Phytother Res 23(1): 72- 77. [Impact factor:2.694]
  • Pathan AR, Gaikwad AB, Viswanad B, Ramarao, P (2008) Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats. Eur J Pharmacol 589(1- 3): 176- 179. [Impact Factor: 2.730]
  • Tikoo K, Meena RL, Kabra DG, Gaikwad AB (2008) Change in post - translational modifications of histone H3, heat - shock protein- 27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br J Pharmacol 153(6): 1225- 1231. [Impact Factor: 5.259]
  • Tikoo K, Singh K, Kabra D, Sharma V, Gaikwad AB (2008) Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy. Free Radic Res 42(4): 397- 404. [Impact Factor: 2.949]
  • Tikoo K, Tamta A, Ali IY, Gupta J, Gaikwad AB (2008) Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation. Toxicol Lett 177(2): 90- 96. [Impact Factor: 3.522]
  • Gaikwad AB, Viswanad B, Ramarao P (2007) PPAR gamma agonists partially restores hyperglycemia induced aggravation of vascular dysfunction to angiotensin II in thoracic aorta isolated from rats with insulin resistance. Pharmacol Res 55(5): 400- 407. [Impact Factor: 4.816]
  • Tikoo K, Bhatt DK, Gaikwad AB, Sharma V, Kabra DG (2007) Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats. FEBS Lett 581(10): 2027- 2035. [Impact Factor: 3.519]
  • Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB (2007) Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53. FEBS Lett 581(5): 1071- 1078. [Impact Factor: 3.519]

Review Articles

  • Pandey A, Gaikwad AB (2017) "AT 2 receptor agonist Compound 21: A silver lining for diabetic nephropathy". Eur J Pharmacol. (In press) [Impact Factor: 2.896].
  • Malek V, Gaikwad AB. (2017) "Neprilysin inhibitors: A new hope to halt the diabetic cardiovascular and renal complications?" Biomed Pharmacother 90:752-759 [Impact Factor: 2.759]
  • Goru SK, Kadakol A, Gaikwad AB. (2017) "Hidden targets of ubiquitin proteasome system: To prevent diabetic nephropathy". Pharmacol Res 120: 170-179 [Impact Factor: 4.816]
  • Kadakol A, Sharma N, Kulkarni YA, Gaikwad AB (2016) "Esculetin: A phytochemical endeavor fortifying effect against non-communicable diseases". Biomed Pharmacother.  84: 1442-1448 [Impact Factor: 2.759]
  • Goru SK, Pandey A, Gaikwad AB. (2016) "E3 ubquitin ligases as novel therapuetic targets for inflammatory diseases". Pharmacol Res. 106: 1–9 [Impact Factor: 4.816]
  • Pandey A, Kumar GS, Kadakol A, Malek V, Gaikwad AB. (2016) "FoxO1 inhibitors: The future medicine for metabolic disorders?". Curr Diabetes Rev. 12:1-8.
  • Pandey A, Malek V, Prabhakar V, Kulkarni YA, and Gaikwad AB. (2015) "Nanoparticles and Neurotoxicity: A Mechanistic Approach". CNS & Neurological Disorders - Drug Targets. 14(10):1317-27.  [Impact Factor: 2.188]
  • Kumar P, Kadakol  AM, Prashanth KS, Nitin AM, Vinayak SJ, Baruad CC and Gaikwad AB, (2015) "Curcumin as an adjuvant to breast cancer treatment". Anti-Cancer Agents in Medicinal Chemistry. 15(6), 647-656. [Impact Factor: 2.722]
  • Gaikwad AB, Vidya S, and Pandey A., (2015) "Natural HDAC Inhibitors: Nature’s Answer to the Cancer". Journal of Pharmaceutical sciences and Technology Management. 1(1), 26-36.
  • Pandey A, Pooja M, Chandak PG and Gaikwad AB. (2014) "PARG Inhibitors Success: A Long Way To Go! ". Current Enzyme Inhibition. 10 (2), 81-93.
  • Woroniecki R, Gaikwad AB, Susztak K (2011) "Fetal environment, epigenetics, and pediatric renal disease". Pediatr Nephrol 26(5): 705- 711. [Impact Factor: 2.338] 

Book Chapters

  • M.J. Oza, M.S. Garud, Gaikwad AB, Y.A. Kulkarni (2017). "Fibromyalgia Syndrome: Role of Obesity and Nutrients, Nutrition and Functional Foods for Healthy Aging". Academic Press: Elsevier, USA. Pp. 53-59.
  • N. Sharma, Gaikwad AB, Y.A. Kulkarni (2017). "Folic Acid in Pain: An Epigenetic Link. In: Nutritional Modulators of Pain in the Aging Population". Academic Press: Elsevier, USA. Pp. 245-251.
  • Y.A. Kulkarni, S.V. Suryavanshi, S.T. Auti, Gaikwad AB (2017). "Capsicum: A Natural Pain Modulator. In: Nutritional Modulators of Pain in the Aging Population". Academic Press: Elsevier, USA. Pp. 107-118.
  • M.S. Garud, M.J. Oza, Gaikwad AB, Y.A. Kulkarni (2017). "Natural Remedies for Treatment of Cancer Pain. In: Nutritional Modulators of Pain in the Aging Population". Academic Press: Elsevier, USA. Pp. 101-106.
  • Y.A. Kulkarni, M.S. Garud, M.J. Oza, Gaikwad AB (2017). "Biomarkers of Multiple Sclerosis and Their Modulation by Natural Products. Nutrition and Lifestyle. In: Neurological Autoimmune Diseases: Multiple Sclerosis". Academic Press: Elsevier, USA. Pp. 275-284.
  • Y.A. Kulkarni, M.S. Garud, M.J. Oza, Barve K H., Gaikwad AB,  (2016). "Diabetes, diabetic complications, and flavonoids. In: Fruits, Vegetables, and Herbs". Academic Press: Elsevier, USA. Pp. 77-104.
  • Y.A. Kulkarni, M.S. Garud, Gaud R.S., Gaikwad AB, (2016). Recent developments in using plant-derived natural products as tubulin inhibitors for the management of cancer. In: Fruits, Vegetables, and Herbs". Academic Press: Elsevier, USA. Pp. 507-524.
  • Barve K H., Y.A. Kulkarni, Gaikwad AB, (2016). Nutraceuticals as therapeutic agents for inflammation. In: Fruits, Vegetables, and Herbs". Academic Press: Elsevier, USA. Pp. 121-147.
  • Pandey A, Y.A. Kulkarni, Gaikwad AB, (2016). "Curcumin: The epigenetic therapy. In: Fruits, Vegetables, and Herbs". Academic Press: Elsevier, USA. Pp.105-119 

Abstracts published in national and international conferences

  • Kadakol A, Goru SK, Pandey A and Gaikwad AB. (2014) "Reno Protective Activity of Esculetin in Insulin Resistant and Type 2 Diabetic Rats."  Journal of the American Society of Nephrology Supplement 25, 962A-PUB 291.
  • Gaikwad AB, B Viswanad and P Ramarao. (2005) Effect of Rosiglitazone on Angiotensin II Mediated Vascular Responses in Thoracic Aorta Isolated from High Fat Diet Fed Streptozotocin Treated Rats”, Indian Journal of Pharmacology Supplement 37, S37.

Posters presented in national and international conferences

  • SG Sayyed, Gaikwad AB, J Lichtnekert, Kulkarni O, Eulberg D, Klussmann S, Kulbhushan T, Anders HJ. Renal and cardiac histone H3 epigenetics in mice with type 2 diabetes and renal failure. American Society of Nephrology 2009, San Diego, USA.
  • Gaikwad AB, SG Sayyed, J Lichtnekert, K Tikoo, HJ Anders. Renal failure increases cardiac histone H3K9 and H3K23 acetylation, H3K4 dimethylation, phosphorylation at serine 10 and reduces the H3K9 dimethylation in type 2 diabetes. Kongress für Nephrologie, 26. bis 29. September 2009 Göttingen, Germany.
  • Gaikwad AB, B Viswanad and P Ramarao. Effect of Rosiglitazone on Angiotensin II Mediated Vascular Responses in Thoracic Aorta Isolated from High Fat Diet Fed Streptozotocin Treated Rats”, 38th Annual Conference of the Indian Pharmacological Society, December 28-30, 2005, Chennai, India.
  • SG Sayyed, Gaikwad AB, J Lichtnekert, O Kulkarni, D Eulberg, S Klussmann, K Tikoo, HJ Anders. CCl2 blockade prevents the development of diabetic nephropathy and alters the post-translational modification of histone h3 in type II diabetic mice. World Congress of Nephrology, 22-26 May 2009, Milan, Italy.
  • SG Sayyed, Gaikwad AB, J Lichtnekert, O Kulkarni, D Eulberg, S Klussmann, K Tikoo, HJ Anders. MCP-1 blockade prevents the epigenetic histone H3 modifications associated with nephropathy in type II diabetic mice. Kongress für Nephrologie, 26. bis 29. September 2009 Göttingen, Germany.
  • Durga Nand Tripathi, Vikram Sharma, Dhiraj Kabra, Gaikwad AB and Kulbhushan Tikoo. Intermittent Fasting impedes the development of streptozotocin induced diabetic nephropathy in male SD rats: evidence for the involvement of a novel “Sir2-p53” axis in diabetes. 75th Annual Meeting of the Society of Biological Chemists, 8-11 December, 2006.
  • Dhiraj Kabra, Karmveer Singh, Vikram Sharma, Gaikwad AB and Kulbhushan Ttikoo. Resveratrol ameliorates STZ induced diabetic nephropathy in rats by changing expression of Sir2, p53, p38 and p-ERK.Nuclear Architecture: Chromosome-Chromatin Dynamics. Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore. 11-13 December, 2006.
  • Vikram Sharma, Deepak Kumar Bhatt, Gaikwad AB, Dhiraj Kabra, and Kulbhushan Tikoo. Tannic acid (Gallotannin) prevents cisplatin induced nephrotoxicity by inhibiting expression of PARP, Caspase-3, p38 and by histone acetylation. Nuclear Architecture: Chromosome-Chromatin Dynamics. Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore. 11-13 December, 2006.

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