Advanced Medicinal Chemistry
Drug development process, drug-receptor interactions, basic drug design approaches, prodrugs and soft drugs. Development, mode of action, structural features, SAR, synthetic approaches and screening method of following class of drugs; chemotherapeutic agents (microbial, parasitic and cancer), cardiovascular (hypertension, arrythmiasis, vasodilators, diuretics, lipid lowering etc), nervous system, metabolic disorders, Gastrointestinal agents, analgesics & anti-inflammatory agents etc. combinatorial chemistry includes Solid-phase organic synthesis – solid support, linker, method de-convolution method with examples
Advanced Pharmaceutical Chemistry
Stereochemistry in drug action, Stereochemistry of ring systems present in pharmaceuticals, Rearrangement reactions and their applications to drug synthesis, Name reactions and examples in drug synthesis.
Logics in organic synthesis; Retrosynthetic analysis including asymmetric synthesis; Pharmaceutical Process chemistry; Introduction, biological properties and synthetic reactions related to heterocyclic ring systems.
Natural Product Chemistry / Phytochemistry
Various separation and characterization techniques involved in natural drug discovery, Chemistry of natural molecules obtained from terrestrial (plants), animal, microbial and marine sources and their role as leads for phyto-pharmaceuticals, Natural molecules under current research and development and standardization of natural formulations.
Computer Aided Molecular Design and Informatics
Computational tools useful for design, drug-receptor interaction modeling, molecular mechanics, quantum mechanics, free energy perturbations, molecular graphics, conformational searching, pharmacophore modeling, 3D QSAR, structure-based drug design, Ligand based drug design, Fragment based drug design, De-novo design, Ab-Initio method, receptor mapping, molecular docking, bioinformatics introduction, cheminformatics, HTVS, Protein modeling and sequence similarity searches for Homology model building.
Quantum mechanics, molecular mechanics force fields, computational interface in molecular geometry, 2D and 3D geometry optimization, Molecular matching and mapping, structure similarity searches, molecular topology, solvent accessible surface analysis Molecular orbital analysis and molecular property calculations, Monte Carlo simulations, Hartree-Fock methods, pharmacophore and QSAR. Protein structure modeling, Generation and analysis of Ramachandran plot, Analysis of protein/DNA complexes
Informatics as a tool, Computer programming useful for Database design and management, softwares useful for database maintenance, structure searching java based tools, introduction to online chemical database resources, and prediction of ADME, toxicity, and HTVS.
Biomolecules an introduction, molecular biophysics, Fundamentals of HTML, NCBI data model, and various file formats of biological sequence, Database tools for macromolecules, primary, secondary and protein sequence database, sequence alignment methods, predictive methods using protein sequence and DNA, Drug design applications.
Chemistry of Macromolecules
Amino acids, peptide synthesis and sequencing. Medicinally important peptides. Peptides and protein conjugation on the surface of nanocarriers, various conjugation techniques.
Natural and synthetic polymers, Polymerization reaction Free radical, anionic and cationic polymerization copolymers, rubbers their stereochemistry and their use in medicine, micelles and micellization, factors affecting micellization, building blocks of polymeric micelles.
Stereochemistry, reactions and medicinal uses of carbohydrates and steroids.
Synthesis and sequencing of nucleic acid. Antiviral and anticancer nucleoside and drug design, concept of siRNA, siRNA delivery, therapeutic application.
Nomenclature, biosynthesis, biological significance and various synthetic approaches of prostaglandins.